Endocrine Abstracts

Introduction: The incidence of primary hyperparathyroidism (PHPT) is ~3.5/100 000 per yearThe incidence is on the rise due to increase in ‘routine biochemical testing’Has been thought to be a ‘relatively harmless’ disorder.Some patients tend to undergo surgery, while others are conservatively treated and most followed up for a short period before discharge from follow up.Aims:<l...

Background: Indeterminate thyroid nodules pose a diagnostic dilemma and the patients often undergo unnecessary surgeries or repeat surgery. Currently different molecular methods for detection of driver mutations are being used for better characterisation of these nodules. These methods are costly and not widely available all over the world. Currently use of liquid biopsy by measurement of cell-free DNA (cfDNA) levels from plasma has been useful in diagnosis and follow up of ca...

Introduction: Molecular testing is being increasingly used to detect malignancy in indeterminate thyroid nodules (Bethesda 3 & 4) which pose diagnostic dilemma. Long non-coding RNAs are crucial for metastasis, angiogenesis, and tumour growth of various cancers. Clinical utility of plasma lncRNAs as non-invasive diagnostic markers for thyroid cancer especially in indeterminate nodule remains unexplored.Methodology: We selected lncRNAs relevant to thyr...

Introduction: Cell-free DNA (cfDNA) integrity in plasma has been investigated as a non-invasive marker in cancer. Thyroid cancer the most common endocrine malignancy sometimes presents as indeterminate nodules and difficult to diagnose without histopathology.Aim of the study: The present study aims to test the hypothesis that the presence of longer DNA strands circulating in plasma can be considered a marker for thyroid cancer.Meth...

Background: Renal involvement in T2DM can be due to diabetes per se (Diabetic Kidney Disease) or causes other than diabetes (non-diabetic kidney disease). Currently available clinical, biochemical, and radiological markers fail to differentiate DKD from NDKD. Renal biopsy remains gold standard for diagnosis. Urinary signatures may provide a non-invasive alternative to that end. In cell culture and in animal models with diabetes and kidney disease, dysregulation of several meta...